Abdulla Fouad For Medical Supplies & Services

SINGLE CELL Research

Advancing Human Health

AFMS partners with 10X Genomics to help researchers deliver powerful, reliable tools that fuel scientific discoveries and drive exponential progress to master biology to advance human health. 10X Genomics' products dissect cell-type differences, detect novel cell subtypes and biomarkers, define gene regulatory interactions, and decipher spatial gene expression patterns.

10X Genomics is engaged in developing an innovative genomics platforms. The company’s product pipeline comprises Chromium X for single-cell gene expression, Visium for spatial transcriptome, and Xenium for in-situ subcellular profiling. 

Cited in more than 4,500 research papers, 10X innovative single cell, spatial, and in situ technologies enable discoveries across oncology, immunology, neuroscience, and more.

10X Genomics also permits to study cellular states in scenarios such as embryonal development, cancer, myoblast and lung epithelium differentiation, and lymphocyte fate diversification. It is also ideal to profile interesting subpopulations of cells from a larger heterogeneous population, for example, malignant tumor cells within a tumor mass, or hyper-responsive immune cells within a seemingly homogeneous group. It can even reveal entirely new cell types.

Applications & Related Products

chromium X

 

Chromium™ X

Next Generation of Single Cell

The Chromium X Series is designed with modern functionality plus enhanced hardware technology to offer the most optimized approach to single cell studies, with the option to match the scale of single cell research at any level and enable routine high throughput experiments.

   Instrument Brochure  
  Explore the Instrument

Single Cell Research

Inside Chromium X:

Single cells, reagents and a single Gel Bead containing barcoded oligonucleotides are encapsulated into nanoliter-sized GEMs (Gel Bead in emulsion) using the GEM code technology.

Lysis and barcoded reverse transcription of polyadenylated mRNA from single cells are performed inside each GEM. High-quality next generation sequencing libraries are finished in single bulk reaction. Finally, 10X special software is utilized for processing, analysis and visualization of single cell gene expression data.

Single-cell Product Offerings:

10x Genomics provides robust solutions that let you analyze gene and protein expression, perform comprehensive immune phenotyping, and map regions of open chromatin, all at single cell resolution.

The company also provides Barcode technology which is compatible with Single Cell Gene Expression and Immune Profiling solutions allowing researchers to simultaneously measure multiple analytes, such as protein and RNA, within the same set of cells or tissues.

  Single Cell Gene Expression Single Cell Immune Profiling

Single Cell Multiome ATAC + Gene Expression 
Description

A flexible solution providing 3' gene expression with multiomic capabilities

 Enhanced immune profiling combining 5' gene expression with multiomic profiling Multiomic profiling of 3' gene expression and open chromatin

Additional multiomic capabilities

Cell Surface Protein

CRISPR Screening

Cell Surface Protein

Antigen Specificity

BCR/TCR sequencing

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Extensions

Sample multiplexing

Automated workflow

 Automated workflow  -
Targeted gene expression panels Human pre-designed and custom; Mouse custom Human pre-designed and custom; Mouse custom   -
Throughput Low, standard, or high Standard or high Standard
Sample & species compatibility

Cells or nuclei

Tested on diverse sample types, including cell lines, primary cells, and dissociated fresh tissue

Demonstrated on multiple species, including human, mouse, and rat

Cells

Tested on diverse sample types, including cell lines, primary cells, and dissociated fresh tissue

Amplification of human or mouse

TCR/BCR sequences

Demonstrated on multiple species, including human and mouse

 

Nuclei

Demonstrated with cell lines, primary cells, cryopreserved samples, and fresh- and flash-frozen tissue

Demonstrated on multiple species, including human, mouse, and rat

 

Visium Spatial Profiling

Novel insights about your tissue. Visualized.

10X Genomics provides Visium spatial gene expression solution for measuring spatial gene expression patterns across a single tissue sample.

Spatial transcriptomics is a groundbreaking molecular profiling method that allows scientists to measure gene activity in a tissue sample and map where the activity is occurring. Visium Spatial Gene Expression spatially resolves gene expression by mapping the whole transcriptome with morphological context in entire formalin fixed paraffin-embedded (FFPE) or fresh frozen tissues to discover novel insights into normal development, disease pathology, and clinical translational research.

   Technology Brochure  
   How it Works!

images/AFMS/Products/Visium Spatial/VisiumSpatial2.png

10x Xenium unit Right elevation

Xenium in-situ Analysis

High-Performance In Situ Gene Expression Mapping

Xenium Analyzer instrument is designed for fully automated high-throughput analysis of cells in their tissue environment. Part of an end-to-end solution that includes pre-designed, validated panels and analysis tools for visualizing and studying spatial patterns of expression, the Xenium Analyzer is next-level in situ. 

Xenium in situ analysis detects and preserves the cellular localization of hundreds of RNA targets directly in a tissue section without the need for conventional sequencing. This provides researchers with a detailed map of gene expression patterns without sacrificing resolution or target number.

   Instrument Brochure  
  View Interactive Data Visualization

 

 

About Us

Contact Us

 Salah Alden Road | Al Zahra District 

Riyadh | Kingdom of Saudi Arabia

 60001 Riyadh 11545

 afms@afmssc.com

 +966 (0) 11 476 7777